참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Cyclopropylethanol | HCID 79104 | — |
| 반응물 | 3-Diazofuran-2,4-dione | HCID 15439113 | — |
| 촉매 | Rhodium acetate | HCID 168478 | — |
| 생성물 | 3-(1-cyclopropylethoxy)-4-hydroxy-2(5H)-furanone | HCID 70106454 | — |
반응 단계
To the mixture of 3-diazo-2,4-(3H, 5H)-furandione (300 mg, 2.38 mmol; Example 207, Step 1) and α-methylcyclopropanemethanol (2.0 mL) was added rhodium acetate (30 mg). The mixture was heated at 130° C. for a period of 18 h. The excess of alcohol was evaporated under reduced pressure and the resulting crude mixture was purified by flash chromatography (10% to 20% MeOH in CH2Cl2 ) to provide 50 mg of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06169188A |
|---|
| 출처 데이터셋 | uspto-grants-2001_01 |
|---|
| ORD ID | ord-98cc1a3b6a024d3ea5342d7c75e3f333 |
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| 출처 메모 | uspto-grants-2001_01 |
|---|
