Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-Methyl-1-[4-(methylthio)phenyl]-1-butanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Thioanisole | HCID 7520 | — |
| 반응물 | Butanoyl chloride, 2-methyl- | HCID 93697 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 2-Methyl-1-[4-(methylthio)phenyl]-1-butanone | HCID 15480643 | — |
반응 단계
To a suspension of AlCl3 (35.4 g) in CHCl3 (500 mL) at −10° C. was added dropwise 2-methylbutyryl chloride (3.13 g) followed by thioanisole (31.2 mL). The mixture was then stirred at r.t. for 20 min. and was then cooled back to 0° C. Water (200 mL) was then added over 30 min. The CHCl3 layer was separated and dried over MgSO4. After filtration and removal of the solvent, the residue was dried under vacuum at 80° C. for 2 h to give 35 g of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06169188A |
| 출처 데이터셋 | uspto-grants-2001_01 |
| ORD ID | ord-ff075d93be0940fda5eaf795e081ca95 |
| 출처 메모 | uspto-grants-2001_01 |