Water → 2-Methyl-1-[4-(methylthio)phenyl]-1-butanone

HRID 565122

반응식

HRID 565122 반응식
[Al+3].[Cl-].[Cl-].[Cl-].[CH3:5][CH:6]([CH2:10][CH3:11])[C:7](Cl)=[O:8].[C:12]1([S:18][CH3:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.O>C(Cl)(Cl)Cl>[CH3:19][S:18][C:12]1[CH:17]=[CH:16][C:15]([C:7](=[O:8])[CH:6]([CH3:5])[CH2:10][CH3:11])=[CH:14][CH:13]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 7520ThioanisoleHCID 93697Butanoyl chloride, 2-methyl-HCID 6451240Aluminum(III) Chloride

생성물 1

HCID 154806432-Methyl-1-[4-(methylthio)phenyl]-1-butanone

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a suspension of AlCl3 (35.4 g) in CHCl3 (500 mL) at −10° C. was added dropwise 2-methylbutyryl chloride (3.13 g) followed by thioanisole (31.2 mL). The mixture was then stirred at r.t. for 20 min. and was then cooled back to 0° C. Water (200 mL) was then added over 30 min. The CHCl3 layer was separated and dried over MgSO4. After filtration and removal of the solvent, the residue was dried under vacuum at 80° C. for 2 h to give 35 g of the title compound.

후처리

  1. temperaturewas then cooled back to 0° C
  2. customThe CHCl3 layer was separated
  3. dry with materialdried over MgSO4
  4. filtrationAfter filtration and removal of the solvent
  5. customthe residue was dried under vacuum at 80° C. for 2 h

출처 및 근거

ORD 기록
ord-ff075d93be0940fda5eaf795e081ca95
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06169188A

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