Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acridine Orange Base → 10-N(10-Hydroxy-1-decyl)-3,6 bis(dimethylamino)acridine bromide salt
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acridine Orange Base | HCID 62344 | — |
| 반응물 | 1-Decanol, 10-bromo- | HCID 104507 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 10-N(10-Hydroxy-1-decyl)-3,6 bis(dimethylamino)acridine bromide salt | HCID 86753341 | — |
반응 단계
3,6-bis(dimethylamino)acridine (1.0 millimole) is dissolved in DMF (100 mL) containing 1.1 equivalent of tertiary amine base. To this is added 10-hydroxy-1-bromo decane (1.1 millimole), and the mixture is heated to reflux. When monitoring by TLC shows no remaining 3,6-bis(dimethylamino)acridine, the reaction is cooled and the 10-N-(10-hydroxy-1-decyl)-3,6-bis(dimethylamino)acridine is isolated (0.75 millimoles).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06171859B2 |
| 출처 데이터셋 | uspto-grants-2001_01 |
| ORD ID | ord-f6ff3aea167649f4b9996cc75b799635 |
| 출처 메모 | uspto-grants-2001_01 |