Ethanol → Ethyl 2-(2-chloroethoxy)acetate

HRID 565182

반응식

HRID 565182 반응식
[Cl:1][CH2:2][CH2:3][O:4][CH2:5][C:6]([OH:8])=[O:7].OS(O)(=O)=O.[CH2:14](O)[CH3:15]>>[CH2:14]([O:7][C:6](=[O:8])[CH2:5][O:4][CH2:3][CH2:2][Cl:1])[CH3:15]

참가 물질

4

반응물 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 109205842-(2-Chloroethoxy)acetic acid

생성물 1

HCID 10964894Ethyl 2-(2-chloroethoxy)acetate수율 89%

실험 절차

54.1 g (390 mmol) M24 obtained from the preceding reaction step was dissolved in 380 ml absolute ethanol and 9 ml conc. H2SO4 was added. The mixture was heated at reflux for 18 hours. Most of the ethanol was evaporated and the residue was dissolved in 400 ml CHCl3/100 ml water and basified with powder NaHCO3. The organic phase was washed with 2×400 ml saturated NaHCO3 and dried over Na2SO4. The solvent was evaporated to afford 58.3 g clear oil (yield: 89%).

후처리

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 18 hours
  3. customMost of the ethanol was evaporated
  4. dissolutionthe residue was dissolved in 400 ml CHCl3/100 ml water and basified with powder NaHCO3
  5. washThe organic phase was washed with 2×400 ml saturated NaHCO3
  6. dry with materialdried over Na2SO4
  7. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-05a4b7d3991b4ddcb9ef706af3926760
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06171866B2

연결된 노트

불러오는 중…