2,4-Difluorobenzaldehyde → HCID 54311230, 화합물

HRID 565217노트

반응식

HRID 565217 반응식
[C:1]([CH2:5][C:6]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:7])(=[O:4])[CH2:2][CH3:3].[F:16][C:17]1[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:18]=1[CH:19]=O>C1C=CC=CC=1.C([O-])(=O)C.[NH2+]1CCCCC1>[F:16][C:17]1[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:18]=1[CH:19]=[C:5]([C:1](=[O:4])[CH2:2][CH3:3])[C:6]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:7]

참가 물질

5

반응물 2

HCID 737702,4-DifluorobenzaldehydeHCID 12425357HCID 12425357, 화합물

생성물 1

HCID 54311230HCID 54311230, 화합물수율 100.3%

시약·촉매·용매 2

HCID 3014295Piperidinium acetate촉매HCID 241Benzene용매

실험 절차

A solution of benzyl propionylacetate (157 g, 0.758 mol), 2,4-difluorobenzaldehyde (107.65 g, 0.758 mol), and piperidinium acetate (5.49 g, 38 mmol) in benzene (1 L) were stirred at room temperature for 96 h. The mixture was washed with water (2×100 mL), dried (magnesium sulfate) and the solvent evaporated under reduced pressure to yield the product as a pale yellow syrup (251.2 g) which was used in the next step without further purification.

후처리

  1. washThe mixture was washed with water (2×100 mL)
  2. dry with materialdried (magnesium sulfate)
  3. customthe solvent evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-e6e121c901fb40bc93d2b5e9f258c83b
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06172066B2

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