Oxalyl chloride → (r)-3-Triisopropylsilyloxybutyryl chloride

HRID 565437노트

반응식

HRID 565437 반응식
[CH:1]([Si:4]([CH:15]([CH3:17])[CH3:16])([CH:12]([CH3:14])[CH3:13])[O:5][C@H:6]([CH3:11])[CH2:7][C:8](O)=[O:9])([CH3:3])[CH3:2].C(Cl)(=O)C([Cl:21])=O>ClCCl>[CH:1]([Si:4]([CH:15]([CH3:17])[CH3:16])([CH:12]([CH3:14])[CH3:13])[O:5][C@H:6]([CH3:11])[CH2:7][C:8]([Cl:21])=[O:9])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 14084664(r)-3-Triisopropylsilyloxybutyric acid

생성물 1

HCID 14084666(r)-3-Triisopropylsilyloxybutyryl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

0.0475 mol (12.36 g ) of the product from stage 2 is dissolved in 200 ml of absolute dichloromethane and treated with stirring with 0.0523 mol (6.64 g) of oxalyl chloride. After 5 hours at room temperature, the mixture is concentrated under reduced pressure.

후처리

  1. additiontreated
  2. concentrationthe mixture is concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-4e4be5571e5f434a9b027812224dbd29
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06172103B2

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