Piperazine → N-(3-benzhydroxypropyl)piperazine

HRID 565633노트

반응식

HRID 565633 반응식
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:7]1([CH:13]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[O:14][CH2:15][CH2:16][CH2:17]Br)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C(O)C.[Na+].[Cl-]>[C:19]1([CH:13]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[O:14][CH2:15][CH2:16][CH2:17][N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

참가 물질

5

반응물 2

HCID 4837PiperazineHCID 143063671-(Diphenylmethoxy)-3-bromopropane

생성물 1

HCID 22110970N-(3-benzhydroxypropyl)piperazine수율 99.7%

시약·촉매·용매 2

HCID 702Ethanol용매2회HCID 5234Sodium Chloride용매

반응 조건

온도
70 °C

실험 절차

In 20 mL of ethanol was dissolved 20 g of piperazine with heating. Then, a solution of 3-(diphenylmethoxy)propyl bromide (7.0 g) in ethanol (20 mL) was added dropwise and the mixture was stirred at 70° C. for 1 hour. This reaction mixture was diluted with saturated aqueous NaCl and extracted with chloroform. The extract was washed with saturated aqueous NaCl to remove the starting material piperazine, dried over MgSO4, and concentrated under reduced pressure to provide 7.1 g of the title compound. Yield 99%. This product was not further purified but directly submitted to the next reaction.

후처리

  1. temperaturewith heating
  2. extractionextracted with chloroform
  3. washThe extract was washed with saturated aqueous NaCl
  4. customto remove the starting material piperazine
  5. dry with materialdried over MgSO4
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-546818fe66f54360b2ea26b4243be733
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06172085B2

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