Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Indole → 1-Phenyl-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Indole | HCID 798 | — |
| 반응물 | Potassium Bicarbonate | HCID 516893 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Bromobenzene | HCID 7961 | — |
| 생성물 | 1-Phenyl-1H-indole | HCID 182029 | 124.2% |
반응 단계
A suspension of indole (8.2 g), potassium bicarbonate (12 g) and copper (I) iodide (2.7 g) in bromobenzene (70 mL) was refluxed for 3 hours under nitrogen atmosphere. To the mixture copper (I) iodide (11 g) was added and the mixture was refluxed for additional 6 hours. The insoluble material was removed by filtration and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=50:1 to 20:1) to provide 8.4 g of the title compound. Yield 62%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06172085B2 |
| 출처 데이터셋 | uspto-grants-2001_01 |
| ORD ID | ord-df943a1910d34487b1cad511b5518662 |
| 출처 메모 | uspto-grants-2001_01 |