1-(4-Nitrobenzyl)piperidine → 4-(Piperidin-1-ylmethyl)aniline

HRID 565831

반응식

HRID 565831 반응식
[N+:1]([C:4]1[CH:16]=[CH:15][C:7]([CH2:8][N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:6][CH:5]=1)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:16]=[CH:15][C:7]([CH2:8][N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:6][CH:5]=1

참가 물질

4

반응물 1

HCID 7835411-(4-Nitrobenzyl)piperidine

생성물 1

HCID 8461504-(Piperidin-1-ylmethyl)aniline수율 18.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

In ethanol (50 ml) was dissolved 1-(4-nitrobenzyl)piperidine (6.41 g), and 10% dried palladium on carbon (0.33 g) was added to the mixture. Under hydrogen atmosphere, the mixture was stirred at room temperature under atmospheric pressure for 24 hours. The palladium was filtered off, and the filtrate was concentrated. The residue was recrystallized from hexane to give 1-(4-aminobenzyl)piperidine (1.01 g) as pale yellow crystals.

후처리

  1. additionwas added to the mixture
  2. filtrationThe palladium was filtered off
  3. concentrationthe filtrate was concentrated
  4. customThe residue was recrystallized from hexane

출처 및 근거

ORD 기록
ord-503b4ff6a8fa4e7798c018ced35f5f00
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06172061B2

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