N,N-Dimethyl-4-nitrobenzylamine → Benzenemethanamine, 4-amino-N,N-dimethyl-

HRID 565840노트

반응식

HRID 565840 반응식
[CH3:1][N:2]([CH3:13])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-])=O)=[CH:6][CH:5]=1>C(O)C>[NH2:10][C:7]1[CH:6]=[CH:5][C:4]([CH2:3][N:2]([CH3:13])[CH3:1])=[CH:9][CH:8]=1

참가 물질

3

반응물 1

HCID 278498N,N-Dimethyl-4-nitrobenzylamine

생성물 1

HCID 308051Benzenemethanamine, 4-amino-N,N-dimethyl-수율 50.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

In ethanol (100 ml) was dissolved dimethyl-4-nitrobenzylamine (20.7 g), and to the mixture was added dried 10% palladium on carbon (1.00 g). Under hydrogen atmosphere, the mixture was stirred at room temperature under atmospheric pressure for 20 hours. The palladium was filtered off, and the filtrate was concentrated. The residue was separated and purified with column chromatography (ethyl acetate) to give 4-aminobenzyldimethylamine (8.75 g) as pale yellow oil.

후처리

  1. additionto the mixture was added
  2. dry with materialdried 10% palladium on carbon (1.00 g)
  3. filtrationThe palladium was filtered off
  4. concentrationthe filtrate was concentrated
  5. customThe residue was separated
  6. custompurified with column chromatography (ethyl acetate)

출처 및 근거

ORD 기록
ord-1193b37cfa4b47d1935fa5fae2b6df78
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06172061B2

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