tert-Butyl 2-bromopropanoate → tert-Butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)propanoate

반응식

[Br:1][C:2]1[CH:7]=[CH:6][NH:5][C:4](=[O:8])[CH:3]=1.Br[CH:10]([CH3:18])[C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12]>>[Br:1][C:2]1[CH:7]=[CH:6][N:5]([CH:10]([CH3:18])[C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[C:4](=[O:8])[CH:3]=1

참가 물질

반응물 2

HCID 545327tert-Butyl 2-bromopropanoate

HCID 8171154-Bromo-2-hydroxypyridine

생성물 1

HCID 117622807tert-Butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)propanoate

실험 절차

6.0 g (34.5 mmol) of 4-bromopyridin-2(1H)-one and 7.9 g (37.9 mmol) of tert-butyl 2-bromopropanoate (racemate) were reacted according to General Method 4B. After removal of the DMF, the desired product was precipitated with water and then purified further by flash chromatography (silica gel 60, mobile phase: cyclohexane/ethyl acetate mixtures). Yield: 7.4 g (69% of theory)

후처리

customAfter removal of the DMF
customthe desired product was precipitated with water
custompurified further by flash chromatography (silica gel 60, mobile phase: cyclohexane/ethyl acetate mixtures)

출처 및 근거

ORD 기록: ord-a3d9a6c70f324a2bbe12ad35708693af
출처 데이터셋: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09434690B2

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