Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzeneacetic acid, 3,4-dimethoxy-, methyl ester → 6-(3,4-Dimethoxy-benzyl)-1-(3-nonyl)-3-methyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzeneacetic acid, 3,4-dimethoxy-, methyl ester | HCID 85213 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 반응물 | HCID 59932347 | HCID 59932347 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 6-(3,4-Dimethoxy-benzyl)-1-(3-nonyl)-3-methyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one | HCID 136132156 | 48% |
반응 단계
10 mg (0.036 mmol) of 5-amino-3-methyl-(3-nonyl)-1H-pyrazole-4-carboxamide and 57 mg (0.274 mmol) of methyl 3,4-dimethoxyphenylacetate are refluxed for 6 hours in 0.5 ml of a 0.5M ethanolic sodium ethoxide solution. After dichloromethane and saturated aqueous sodium hydrogen carbonate solution have been added, the phases are separated. Purification by chromatography gives 7.3 mg (48%) of a solid, Rf=0.57 (dichloromethane/methanol=15:1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06174884B1 |
| 출처 데이터셋 | uspto-grants-2001_01 |
| ORD ID | ord-d1a64a1cd3d14eaca0c645f9927cdb7a |
| 출처 메모 | uspto-grants-2001_01 |