tert-Butyl 2-bromopropanoate → tert-Butyl 2-[4-{5-chloro-2-[(trimethylsilyl)ethynyl]phenyl}-2-oxopyridin-1(2H)-yl]propanoate
반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:15]#[C:16][Si:17]([CH3:20])([CH3:19])[CH3:18])=[C:6]([C:8]2[CH:13]=[CH:12][NH:11][C:10](=[O:14])[CH:9]=2)[CH:7]=1.Br[CH:22]([CH3:30])[C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:15]#[C:16][Si:17]([CH3:19])([CH3:18])[CH3:20])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]([CH:22]([CH3:30])[C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[C:10](=[O:14])[CH:9]=2)[CH:7]=1참가 물질
3
실험 절차
125 mg (purity 91%, 0.38 mmol) of 4-{5-chloro-2-[(trimethylsilyl)ethynyl]phenyl}pyridin-2(1H)-one and 1.2 eq. of tert-butyl 2-bromopropanoate (racemate) were reacted at 80° C. according to General Method 4B. Yield: 56 mg (purity 89%, 31% of theory)
출처 및 근거
- ORD 기록
- ord-68e0b47f566a464c81190df14b1fef97
- 출처 데이터셋
- uspto-grants-2016_09