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2,2-Di{4-[difluoro(phosphono)methyl]benzyl}malonic acid, dibenzyl ester → 2,2-Di{4-[Difluoro(Phosphono)Methyl]Benzyl}Malonic Acid

HRID 566499
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HRID 566499 반응식
[F:1][C:2]([F:49])([P:45]([OH:48])([OH:47])=[O:46])[C:3]1[CH:44]=[CH:43][C:6]([CH2:7][C:8]([CH2:29][C:30]2[CH:35]=[CH:34][C:33]([C:36]([F:42])([F:41])[P:37]([OH:40])([OH:39])=[O:38])=[CH:32][CH:31]=2)([C:19]([O:21]CC2C=CC=CC=2)=[O:20])[C:9]([O:11]CC2C=CC=CC=2)=[O:10])=[CH:5][CH:4]=1>C(O)=O.CO.Cl[Pd]Cl>[F:42][C:36]([F:41])([P:37]([OH:40])([OH:39])=[O:38])[C:33]1[CH:34]=[CH:35][C:30]([CH2:29][C:8]([CH2:7][C:6]2[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:49])[P:45]([OH:48])([OH:47])=[O:46])=[CH:44][CH:43]=2)([C:19]([OH:21])=[O:20])[C:9]([OH:11])=[O:10])=[CH:31][CH:32]=1
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참가 물질

5

반응물 1

HCID 154858912,2-Di{4-[difluoro(phosphono)methyl]benzyl}malonic acid, dibenzyl ester

생성물 1

HCID 212656882,2-Di{4-[Difluoro(Phosphono)Methyl]Benzyl}Malonic Acid수율 66.6%

시약·촉매·용매 3

HCID 284Formic Acid촉매HCID 24290Palladium Chloride촉매HCID 887Methanol용매

실험 절차

A mixture of the product of Example 2 (0.2 g), PdCl2 and a few drops of HCO2H in 20 mL of MeOH was shaken under 50 psi of H2 for 24 h. The reaction mixture was filtered through celite and the filtrate was concentrated. The residue was lyopholized to give 0.1 g of the title compound.

후처리

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-652f38ba5d8c4e6db5c507ec144e985d
출처 데이터셋
uspto-grants-2001_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06174874B1

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