참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Lithium Bromide | HCID 82050 | — |
| 반응물 | 4-Bromo-2-hydroxypyridine | HCID 817115 | — |
| 반응물 | Ethyl 3-cyclopropyl-2-[(methylsulphonyl)oxy]propanoate | HCID 117605475 | — |
| 생성물 | Ethyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-cyclopropylpropanoate | HCID 117622870 | — |
반응 단계
1.02 g (5.87 mmol) of 4-bromopyridin-2(1H)-one and 2.23 g (purity 56%, 5.28 mmol) of ethyl 3-cyclopropyl-2-[(methylsulphonyl)oxy]propanoate (racemate) in the presence of 1.15 eq. of sodium hydride and 2.3 eq. of lithium bromide were reacted according to General Method 4C (stirred at 65° C. overnight). Yield: 246 mg (13% of theory)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09434690B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_09 |
|---|
| ORD ID | ord-e4b0243d8a54422bb0021d2b39bd193f |
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| 출처 메모 | uspto-grants-2016_09 |
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