Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
L-2-aminohexano-6-lactam → 3(RS)-(3-Biphenyl-4-yl-1H-imidazol-1-yl)-N-(hexahydroazepin-2-on-3(S)-yl]succinamic Acid Benzyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | L-2-aminohexano-6-lactam | HCID 440599 | — |
| 반응물 | 2(RS)-(3-biphenyl4-yl-1H-imidazol-1-yl)-succinic acid 4-benzyl ester | HCID 54141298 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3(RS)-(3-Biphenyl-4-yl-1H-imidazol-1-yl)-N-(hexahydroazepin-2-on-3(S)-yl]succinamic Acid Benzyl Ester | HCID 53846884 | 67.2% |
반응 단계
According to the procedure described in Example 8(a), 2(RS)-(3-biphenyl-4-yl-1H-imidazol-1-yl)-succinic acid 4-benzyl ester (1.20 g, 2.82 mmol) and L-α-amino-ε-caprolactam (469 mg, 3.67 mmol) was coupled in DMF with pyBOP to furnish 1.02 g (67%) of 3(RS)-(3-biphenyl-4-yl-1H-imidazol-1-yl)-N-(hexahydroazepin-2-on-3(S)-yl)succinamic acid benzyl ester. FABMS: 537.5 (C32H33N4O4; M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06174915B1 |
| 출처 데이터셋 | uspto-grants-2001_01 |
| ORD ID | ord-0e9f6831edb34664b07b755f431ed574 |
| 출처 메모 | uspto-grants-2001_01 |