3-(Benzyloxy)-2-methylpyridin-4(1H)-one → 3-(Benzyloxy)-2-methylpyridin-4(1H)-one

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[CH3:1][C:2]1[NH:3][CH:4]=[CH:5][C:6](=[O:16])[C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[O:17]=[CH:18][C@@H:19]([C@H:21]([C@@H:23]([CH2:25][OH:26])[OH:24])[OH:22])[OH:20].[CH3:27][C:28]([CH3:30])=[O:29]>ClCCl.C(OCC)C>[CH3:1][C:2]1[NH:3][CH:4]=[CH:5][C:6](=[O:16])[C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[O:17]=[CH:18][C@@H:19]([C@H:21]([C@@H:23]([CH2:25][OH:26])[OH:24])[OH:22])[OH:20].[CH3:27][C:28]([CH3:30])=[O:29].[CH3:2][C:7]([CH3:6])=[O:8]

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실험 절차

The 2-methyl-3-benzyloxypyridine-4(1H)-one of diacetone xylose is prepared according to the method described in example 2. Starting from 4.50 g (23.8 mmol) of 5-amino-5-desoxy-mono-acetone xylose compound, after re-crystallization in a dichloromethane-ethyl ether mixture, 3.87 g (9.98 mmol) of 2-methyl-3-benzyloxypyridine-4(1H)-one of mono-acetone xylose is isolated, which is pure at chromatographic and NMR analyses. Yield: 42%.