Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydrofuran → 2-Fluoro-9-phenylfluoren-9-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Fluorofluorenone | HCID 70093312 | — |
| 반응물 | HCID 178506676 | HCID 178506676 | — |
| 용매 | Cyclohexane diethylether | HCID 21895417 | — |
| 생성물 | 2-Fluoro-9-phenylfluoren-9-ol | HCID 21263963 | 90% |
반응 단계
To a stirred, ice-cooled solution of 2-fluorofluorenone (2.0 g, 10 mmol) in 15 mL of dry THF under N2 was added 10 mL of 2.4 M phenyllithium solution in cyclohexane-Et2O (7:3), keeping T<20° C. The mixture was quenched with water and the product isolated with EtOAc and purified by flash chromatography (7% EtOAc-hexanes) to give 2.52 g (90%) of 2-fluoro-9-phenylfluoren-9-ol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06177427B1 |
| 출처 데이터셋 | uspto-grants-2001_01 |
| ORD ID | ord-28b14d14aa0040648ba12bf59967ae09 |
| 출처 메모 | uspto-grants-2001_01 |