2-Bromo-4-chlorobenzonitrile → 4-Chloro-2-(5-fluoro-2-methoxypyridin-4-yl)benzonitrile

HRID 56691

반응식

HRID 56691 반응식
[F:1][C:2]1[C:3](B(O)O)=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1.Br[C:14]1[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:15]=1[C:16]#[N:17]>>[Cl:22][C:20]1[CH:21]=[CH:14][C:15]([C:16]#[N:17])=[C:18]([C:3]2[C:2]([F:1])=[CH:7][N:6]=[C:5]([O:8][CH3:9])[CH:4]=2)[CH:19]=1

참가 물질

3

반응물 2

HCID 234985242-Bromo-4-chlorobenzonitrileHCID 44754837(5-Fluoro-2-methoxypyridin-4-yl)boronic acid

생성물 1

HCID 1176048444-Chloro-2-(5-fluoro-2-methoxypyridin-4-yl)benzonitrile

실험 절차

256 mg (1.5 mmol) of 5-fluoro-2-methoxypyridin-4-ylboronic acid and 295 mg (1.34 mmol) of 2-bromo-4-chlorobenzonitrile were reacted according to General Method 2A. The product was precipitated with water. Yield: 146 mg (37% of theory)

후처리

  1. customThe product was precipitated with water

출처 및 근거

ORD 기록
ord-aad9eac189c54f3bbd710f994a998d10
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434690B2

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