Thionyl Chloride → 3,3-Difluorooxolane-2,5-dione

HRID 566959노트

반응식

HRID 566959 반응식
[F:1][C:2]([F:10])([CH2:6][C:7]([OH:9])=[O:8])[C:3](O)=[O:4].S(Cl)(Cl)=O>C1C=CC=CC=1>[F:1][C:2]1([F:10])[CH2:6][C:7](=[O:9])[O:8][C:3]1=[O:4]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 695812,2-Difluorosuccinic acid

생성물 1

HCID 131892433,3-Difluorooxolane-2,5-dione수율 83%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

A mixture of 2,2-difluorosuccinic acid (1.15 g, 7.46 mmol), thionyl chloride (4 mL, 20.6 mmol) and benzene (4 mL) was heated at reflux for 2.5 h. The mixture was filtered and the filtrate was concentrated to afford the title product as an oil that crystallized on standing (838 mg, 6.16 mmol, 83% yield).

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 2.5 h
  3. filtrationThe mixture was filtered
  4. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-036ddd05d94a4024a6a0c2a972faa8d2
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06177445B1

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