Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Einecs 211-027-4 → 5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]pyridin-2(1H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Einecs 211-027-4 | HCID 69401 | — |
| 반응물 | 5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]-2-methoxypyridine | HCID 117604825 | — |
| 생성물 | 5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]pyridin-2(1H)-one | HCID 117605586 | — |
반응 단계
305 mg (purity 77%, 0.77 mmol) of 5-chloro-4-[5-chloro-2-(difluoromethyl)phenyl]-2-methoxypyridine and 20 eq. of pyridinium chloride were reacted according to General Method 3A. After work-up, the crude product was purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient). Yield: 179 mg (80% of theory)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09434690B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-b098b5f42e87484490369782a0a6d1f2 |
| 출처 메모 | uspto-grants-2016_09 |