Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Bromopropionic acid → 2-{5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}propanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Bromopropionic acid | HCID 11729 | — |
| 반응물 | 5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]pyridin-2(1H)-one | HCID 117605586 | — |
| 생성물 | 2-{5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}propanoic acid | HCID 117622899 | — |
반응 단계
118 mg (0.41 mmol) of 5-chloro-4-[5-chloro-2-(difluoromethyl)phenyl]pyridin-2(1H)-one and 1.5 eq. of 2-bromopropanoic acid (racemate) were reacted according to General Method 4A at 35° C. Yield: 112 mg (76% of theory)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09434690B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-f46809968d4f4934871de5b1cc97ab55 |
| 출처 메모 | uspto-grants-2016_09 |