Benzeneethanamine, 4-nitro-, hydrochloride (1:1) → (s)-1-Phenoxy-3-[[2-(4-nitrophenyl)ethyl]amino]-2-propanol

HRID 567082노트

반응식

HRID 567082 반응식
[O:1]([CH2:8][C@@H:9]1[CH2:11][O:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[N+:13]([C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][NH2:24])=[CH:18][CH:17]=1)([O-:15])=[O:14]>C(N(CC)CC)C>[O:1]([CH2:8][C@@H:9]([OH:10])[CH2:11][NH:24][CH2:23][CH2:22][C:19]1[CH:18]=[CH:17][C:16]([N+:13]([O-:15])=[O:14])=[CH:21][CH:20]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 458983Benzeneethanamine, 4-nitro-, hydrochloride (1:1)HCID 1534345(2S)-2-(phenoxymethyl)oxirane

생성물 1

HCID 53932073(s)-1-Phenoxy-3-[[2-(4-nitrophenyl)ethyl]amino]-2-propanol수율 39.3%

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

7.71 g of (S)-2-phenoxymethyloxirane and 10.34 g of 2-(4-nitrophenyl)ethylamine hydrochloride were subjected to a ring-opening reaction in the presence of 5.20 g of triethylamine to obtain 6.35 g of (S)-1-phenoxy-3-[[2-(4-nitrophenyl)ethyl]amino]-2-propanol.

출처 및 근거

ORD 기록
ord-2ee66b0f78b84c239bb91ff1932ac374
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06177454B1

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