(5-Chloro-2-methoxypyridin-4-yl)boronic acid → 5-Chloro-4-[5-chloro-2-(trifluoromethyl)phenyl]-2-methoxypyridine

HRID 56709

반응식

HRID 56709 반응식
[Cl:1][C:2]1[C:3](B(O)O)=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1.Br[C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:15]=1[C:21]([F:24])([F:23])[F:22]>CC(C1C=C(C(C)C)C(C2C(P(C3CCCCC3)C3CCCCC3)=CC=CC=2)=C(C(C)C)C=1)C.C1C=[C-]C(CCN)=CC=1.Cl[Pd+]>[Cl:1][C:2]1[C:3]([C:16]2[CH:17]=[C:18]([Cl:20])[CH:19]=[CH:14][C:15]=2[C:21]([F:22])([F:23])[F:24])=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1

참가 물질

4

반응물 2

HCID 11030558(5-Chloro-2-methoxypyridin-4-yl)boronic acidHCID 202698572-Bromo-4-chloro-1-(trifluoromethyl)benzene

생성물 1

HCID 1176056205-Chloro-4-[5-chloro-2-(trifluoromethyl)phenyl]-2-methoxypyridine

시약·촉매·용매 1

HCID 54751079XPhos Palladacycle촉매

실험 절차

443 mg (2.20 mmol) of 5-chloro-2-methoxypyridin-4-ylboronic acid and 571 mg (2.20 mmol) of 2-bromo-4-chloro-1-(trifluoromethyl)benzene in the presence of XPhos precatalyst were reacted according to General Method 2B. Yield: 193 mg (purity 93%, 25% of theory)

출처 및 근거

ORD 기록
ord-fa6e63b98ed947ad9d7b691e79ba8e50
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434690B2

연결된 노트

불러오는 중…