Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Bromopropionic acid → 2-[4-(5-Chloro-2-cyanophenyl)-5-cyano-2-oxopyridin-1(2H)-yl]propanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Bromopropionic acid | HCID 11729 | — |
| 반응물 | 4-(5-Chloro-2-cyanophenyl)-6-oxo-1,6-dihydropyridin-3-carbonitrile | HCID 117605665 | — |
| 생성물 | 2-[4-(5-Chloro-2-cyanophenyl)-5-cyano-2-oxopyridin-1(2H)-yl]propanoic acid | HCID 117622765 | — |
반응 단계
312 mg (purity 91%, 1.11 mmol) of 4-(5-chloro-2-cyanophenyl)-6-oxo-1,6-dihydropyridin-3-carbonitrile and 1.5 eq. of 2-bromopropanoic acid (racemate) were reacted according to General Method 4A at 45° C. Yield: 240 mg (purity 85%, 56% of theory)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09434690B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-18db1e831c1f4d97889247fdc84cacdc |
| 출처 메모 | uspto-grants-2016_09 |