2-Bromo-4-chlorobenzonitrile → 4-Chloro-2-[2-methoxy-5-(trifluoromethyl)pyridin-4-yl]benzonitrile

반응식

[CH3:1][O:2][C:3]1[CH:8]=[C:7](B(O)O)[C:6]([C:12]([F:15])([F:14])[F:13])=[CH:5][N:4]=1.Br[C:17]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:18]=1[C:19]#[N:20]>>[Cl:25][C:23]1[CH:24]=[CH:17][C:18]([C:19]#[N:20])=[C:21]([C:7]2[C:6]([C:12]([F:15])([F:14])[F:13])=[CH:5][N:4]=[C:3]([O:2][CH3:1])[CH:8]=2)[CH:22]=1

참가 물질

반응물 2

HCID 234985242-Bromo-4-chlorobenzonitrile

HCID 118704437(2-Methoxy-5-(trifluoromethyl)pyridin-4-yl)boronic acid

생성물 1

HCID 1176057584-Chloro-2-[2-methoxy-5-(trifluoromethyl)pyridin-4-yl]benzonitrile

실험 절차

1.0 g (4.4 mmol) of 2-methoxy-5-trifluoromethylpyridin-4-ylboronic acid and 0.95 g (4.4 mmol) of 2-bromo-4-chlorobenzonitrile in the presence of [1,1-bis(diphenylphosphino)ferrocene]palladium(II) chloride/dichloromethane monoadduct were reacted according to General Method 2A. Yield: 351 mg (purity 71%, 18% of theory)

출처 및 근거

ORD 기록: ord-1fa0044468674d8d8fcdb79c4ca3d961
출처 데이터셋: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09434690B2

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