Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Toluenesulfonic acid → 2-Methoxy-5-((tetrahydro-2H-pyran-2-yl)oxy)pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| 반응물 | 5-Hydroxy-2-methoxypyridine | HCID 11622335 | — |
| 반응물 | Water methylene chloride | HCID 21908982 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Methoxy-5-((tetrahydro-2H-pyran-2-yl)oxy)pyridine | HCID 117622661 | — |
반응 단계
10.1 g (119.9 mmol, 1.5 eq.) of 3,4-dihydro-2H-pyran and 1.4 g (8.0 mmol, 0.1 eq.) of 4-toluenesulphonic acid were added to a solution of 10.0 g (79.9 mmol) of 6-methoxypyridin-3-ol in 150 ml of dichloromethane, and the mixture was stirred at RT for 5 d. After addition of water/dichloromethane and phase separation, the aqueous phase was extracted with dichloromethane. The combined organic phases were dried (sodium sulphate), filtered and concentrated under reduced pressure. Yield: 17.3 g (100% of theory)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09434690B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-d6770c83df914ad7bc6d1b64050071cf |
| 출처 메모 | uspto-grants-2016_09 |