반응식
C(N(S(F)(F)F)CC)C.[Cl:10][C:11]1[CH:12]=[CH:13][C:14]([C:41]#[N:42])=[C:15]([C:17]2[C:22]([O:23][CH3:24])=[CH:21][N:20]([CH:25]([CH:33](O)[CH:34]3[CH2:38][CH2:37][O:36][CH2:35]3)[C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[C:19](=[O:40])[CH:18]=2)[CH:16]=1.C(=O)(O)[O-].[Na+]>ClCCl>[Cl:10][C:11]1[CH:12]=[CH:13][C:14]([C:41]#[N:42])=[C:15]([C:17]2[C:22]([O:23][CH3:24])=[CH:21][N:20]([C:25](=[CH:33][CH:34]3[CH2:38][CH2:37][O:36][CH2:35]3)[C:26]([O:28][C:29]([CH3:31])([CH3:30])[CH3:32])=[O:27])[C:19](=[O:40])[CH:18]=2)[CH:16]=1참가 물질
5
반응물 3
생성물 1
시약·촉매·용매 1
실험 절차
At RT, 0.5 ml (3.8 mmol, 1.2 eq.) of diethylaminosulphur trifluoride was added dropwise to a solution of 1.55 mg (3.13 mmol) of tert-butyl 2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-3-hydroxy-3-(tetrahydrofuran-3-yl)propanoate (diastereomer mixture) in 48 ml of dichloromethane, the mixture was stirred at RT for 90 min and 50 ml of dichloromethane and 50 ml of saturated aqueous sodium bicarbonate solution were then added. After phase separation, the aqueous phase was extracted with dichloromethane. The combined organic phases were washed with saturated aqueous sodium chloride solution, dried (sodium sulphate), filtered, concentrated under reduced pressure and dried. Yield: 1.38 g (93% of theory)
후처리
- customAfter phase separation
- extractionthe aqueous phase was extracted with dichloromethane
- washThe combined organic phases were washed with saturated aqueous sodium chloride solution
- dry with materialdried (sodium sulphate)
- filtrationfiltered
- concentrationconcentrated under reduced pressure
- customdried
출처 및 근거
- ORD 기록
- ord-52fe372853a54386b7cb428a3a08a36e
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09434690B2
연결된 노트
불러오는 중…