1-Propanol → Sampatrilat

HRID 567942노트

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HRID 567942 반응식
O.[C:2]([C@H:5]([CH2:27][NH:28][C:29](=[O:41])[C@H:30]([CH2:36][CH2:37][CH2:38][CH2:39][NH2:40])[NH:31][S:32]([CH3:35])(=[O:34])=[O:33])[CH2:6][C:7]1([C:12]([NH:14][C@H:15]([C:24]([OH:26])=[O:25])[CH2:16][C:17]2[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=2)=[O:13])[CH2:11][CH2:10][CH2:9][CH2:8]1)([OH:4])=[O:3].C(O)CC>C(#N)C>[C:2]([C@H:5]([CH2:27][NH:28][C:29](=[O:41])[C@H:30]([CH2:36][CH2:37][CH2:38][CH2:39][NH2:40])[NH:31][S:32]([CH3:35])(=[O:34])=[O:33])[CH2:6][C:7]1([C:12]([NH:14][C@H:15]([C:24]([OH:26])=[O:25])[CH2:16][C:17]2[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=2)=[O:13])[CH2:11][CH2:10][CH2:9][CH2:8]1)([OH:4])=[O:3]

참가 물질

4

반응물 2

HCID 10311-PropanolHCID 86756334HCID 86756334, 화합물

생성물 1

HCID 6324648Sampatrilat

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

(S,S,S)-N-(1-[2-Carboxy-3-(N2-mesyllysylamino)propyl]-1-cyclopentylcarbonyl)tyrosine hydrate (the δ-form, see Preparation 2) (1.0 g) was stirred with either n-propanol or acetonitrile (10 ml) for 24 hours at room temperature. In each case the white solid obtained was collected by filtration and dried to provide the title compound, m.p. 172-176° C.

후처리

  1. customPreparation 2) (1.0 g)
  2. customIn each case the white solid obtained
  3. filtrationwas collected by filtration
  4. customdried

출처 및 근거

ORD 기록
ord-6b682b1f5ed94bd4b8562c1aa519786b
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06180665B2

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