HCID 86756334, 화합물 → Sampatrilat

HRID 567943노트

반응식

HRID 567943 반응식
O.[C:2]([C@H:5]([CH2:27][NH:28][C:29](=[O:41])[C@H:30]([CH2:36][CH2:37][CH2:38][CH2:39][NH2:40])[NH:31][S:32]([CH3:35])(=[O:34])=[O:33])[CH2:6][C:7]1([C:12]([NH:14][C@H:15]([C:24]([OH:26])=[O:25])[CH2:16][C:17]2[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=2)=[O:13])[CH2:11][CH2:10][CH2:9][CH2:8]1)([OH:4])=[O:3]>O.CC(C)=O>[C:2]([C@H:5]([CH2:27][NH:28][C:29](=[O:41])[C@H:30]([CH2:36][CH2:37][CH2:38][CH2:39][NH2:40])[NH:31][S:32]([CH3:35])(=[O:34])=[O:33])[CH2:6][C:7]1([C:12]([NH:14][C@H:15]([C:24]([OH:26])=[O:25])[CH2:16][C:17]2[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=2)=[O:13])[CH2:11][CH2:10][CH2:9][CH2:8]1)([OH:4])=[O:3]

참가 물질

4

반응물 1

HCID 86756334HCID 86756334, 화합물

생성물 1

HCID 6324648Sampatrilat

시약·촉매·용매 2

HCID 180Acetone용매2회HCID 962Water용매

실험 절차

(S,S,S)-N-(1-[2-Carboxy-3-(N2-mesyllysylamino)propyl]-1-cyclopentylcarbonyl)tyrosine hydrate (the δ-form, see Preparation 2) (847.0 g) was dissolved in water (762 ml) and the solution diluted with acetone (1.0 l). This solution was added slowly to vigorously stirred acetone (18.05 l) at room temperature and a white solid precipitated. The mixture was stirred at room temperature for 18 hours, the solid was collected by filtration, washed with acetone and dried to give the title compound as a white solid (775 g), m.p. 179-181° C. Found: C,53.42; H,6.88; N,9.37; S,5.49. C26H40N4O9S requires: C,53.41; H,6.90; N,9.58; S,5.48%.

후처리

  1. customPreparation 2) (847.0 g)
  2. customa white solid precipitated
  3. filtrationthe solid was collected by filtration
  4. washwashed with acetone
  5. customdried

출처 및 근거

ORD 기록
ord-2d8a21e2f32e4ae68eb74d02fae69bf1
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06180665B2

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