1-Amino-2-naphthol → N-(2-hydroxynaphthyl) N'-(2-bromo phenyl) urea

반응식

[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[OH:12].[Br:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[N:20]=[C:21]=[O:22]>>[OH:12][C:3]1[CH:4]=[CH:5][C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]=1[NH:1][C:21]([NH:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[Br:13])=[O:22]

참가 물질

반응물 2

HCID 145351-Amino-2-naphthol

HCID 1370972-Bromophenyl isocyanate

생성물 1

HCID 22011318N-(2-hydroxynaphthyl) N'-(2-bromo phenyl) urea수율 8.4%

실험 절차

The urea was prepared from 1-amino 2-hydroxynapthalene(195 mg, 1 mmol) and 2-bromophenylisocyanate(1 mmol) by general Method B. It was purified by dilution with methylene chloride and precipitation with hexane. Filtering afforded the title compound(0.030 g, 8%). EI-MS m/z 357(M+H)+.

후처리

customIt was purified by dilution with methylene chloride and precipitation with hexane
filtrationFiltering

출처 및 근거

ORD 기록: ord-ca3cbc344ed34db7bc3af4ab29795a80
출처 데이터셋: uspto-grants-2001_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06180675B2

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