2,3-Difluoro-6-nitrophenol → 6-Amino-2,3-difluorophenol

HRID 568006노트

반응식

HRID 568006 반응식
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([N+:9]([O-])=O)[C:3]=1[OH:12]>[Pd]>[OH:12][C:3]1[C:2]([F:1])=[C:7]([F:8])[CH:6]=[CH:5][C:4]=1[NH2:9]

참가 물질

3

반응물 1

HCID 27337452,3-Difluoro-6-nitrophenol

생성물 1

HCID 27784416-Amino-2,3-difluorophenol수율 100.2%

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

2,3 difluoro 6-nitrophenol (2 g, 11 mmol) was treated with 10% Pd/C(1 g) at 23° C. The reaction mixture was flushed with hydrogen gas and the reaction was allowed to stir 12 h before it was filtered through celite. The filtrate was concentrated in vacuo to afforded the title compound (1.6 g, 97%). EI-MS m/z 146(M+H)+.

후처리

  1. customThe reaction mixture was flushed with hydrogen gas
  2. filtrationwas filtered through celite
  3. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-607c90368d084e26b1affed4c15e27d2
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06180675B2

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