(1,1'-Biphenyl)-3-ol, 4-nitro- → 2-Amino-5-phenylphenol

HRID 568010노트

반응식

HRID 568010 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:6][C:5]=1[OH:16])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:6][C:5]=1[OH:16]

참가 물질

4

반응물 1

HCID 87437(1,1'-Biphenyl)-3-ol, 4-nitro-

생성물 1

HCID 203762-Amino-5-phenylphenol

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of 2-nitro 5-phenylphenol(1.2 g, 5.5 mmol) in methanol was treated with 10% Pd/C(1.2 g). The reaction mixture was flushed with hydrogen and allowed to stir overnight. The reaction mixture was filtered through celite and the filtrate was concentrated in vacuo to afford desired (1.01 g, 98%). EI-MS m/z 186(M+H)+.

후처리

  1. customThe reaction mixture was flushed with hydrogen
  2. filtrationThe reaction mixture was filtered through celite
  3. concentrationthe filtrate was concentrated in vacuo
  4. customto afford

출처 및 근거

ORD 기록
ord-ae3410ffb02b4a9a92724183a1fd4f28
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06180675B2

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