참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Fluorobenzene | HCID 10008 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 3-Pyridinecarbonyl chloride, hydrochloride (1:1) | HCID 88438 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 생성물 | (4-Fluorophenyl)(pyridin-3-yl)methanone | HCID 762660 | — |
반응 단계
To a suspension of 140 g of nicotinic acid chloride hydrochloride in 500 ml of fluorobenzene cooled to 0° C. are added 280 g of aluminium chloride portionwise. The mixture is held under reflux for 6 hours, cooled and then poured onto ice. After the addition of sodium hydroxide up to pH=8, the mixture is extracted with dichloromethane. The organic phase is dried over magnesium sulphate and then evaporated under vacuum. The residue crystallises in a pentane/diisopropyl ether mixture giving 108.5 g of 3-(4-fluorobenzoyl)pyridine in the form of crystals melting at 91° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06180651B2 |
|---|
| 출처 데이터셋 | uspto-grants-2001_01 |
|---|
| ORD ID | ord-ffe533d9ce28413ca8cbdc337e853fb3 |
|---|
| 출처 메모 | uspto-grants-2001_01 |
|---|
