Water → Trans-N-(4-bromo-2-methylphenyl)-3-ethoxypropenamide
반응식
[CH2:1]([O:3]/[CH:4]=[CH:5]/[C:6](Cl)=[O:7])[CH3:2].[Br:9][C:10]1[CH:16]=[CH:15][C:13]([NH2:14])=[C:12]([CH3:17])[CH:11]=1.O>N1C=CC=CC=1>[Br:9][C:10]1[CH:16]=[CH:15][C:13]([NH:14][C:6](=[O:7])/[CH:5]=[CH:4]/[O:3][CH2:1][CH3:2])=[C:12]([CH3:17])[CH:11]=1참가 물질
5
실험 절차
Trans-3-ethoxypropenoyl chloride (0.74 g) was added at 0° to a stirred solution of 4-bromo-2-methylaniline (0.93 g) in pyridine (10 cm3). After 0.5 hours water (40 cm3) was added, the solid material was filtered off, washed with water (30 cm3) and dried. The product was recrystallised from ethyl acetate to afford trans-N-(4-bromo-2-methylphenyl)-3-ethoxypropenamide, m.p. 163°-164°, (1.3 g).
후처리
- filtrationthe solid material was filtered off
- washwashed with water (30 cm3)
- customdried
- customThe product was recrystallised from ethyl acetate
출처 및 근거
- ORD 기록
- ord-59ac6bb072e24b90ba5395cc648529d7
- 출처 데이터셋
- uspto-grants-1988_03
- 특허 번호
- US04728654
반응 노트
불러오는 중…