Sodium Methoxide → HCID 14220967, 화합물

HRID 568385노트

반응식

HRID 568385 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH3:12])[CH:11]=1)[N:8]=[C:7](Cl)[CH:6]=[CH:5]2.[CH3:14][O-:15].[Na+]>CO>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH3:12])[CH:11]=1)[N:8]=[C:7]([O:15][CH3:14])[CH:6]=[CH:5]2

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 142210366-Bromo-2-chloro-8-methylquinoline

생성물 1

HCID 14220967HCID 14220967, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 6-bromo-2-chloro-8-methylquinoline (10.7 g) in methanol (80 cm3) was heated under reflux with a solution of sodium methoxide [made from sodium (2.76 g) in methanol (50 cm3)] for 24 hours. The cooled solution was then evaporated in vacuo and the residue was partitioned between chloroform (100 cm3) and water (50 cm3). The aqueous phase was further extracted with chloroform (2×50 cm3) and the combined and dried (MgSO4) organic phases were evaporated in vacuo to give a solid which was recrystallised from ethyl acetate:hexane, 1:9, to afford 6-bromo-2-methoxy-8-methylquinoline, m.p. 89°-91° (8.3 g).

후처리

  1. customThe cooled solution was then evaporated in vacuo
  2. customthe residue was partitioned between chloroform (100 cm3) and water (50 cm3)
  3. extractionThe aqueous phase was further extracted with chloroform (2×50 cm3)
  4. dry with materialdried (MgSO4) organic phases
  5. customwere evaporated in vacuo
  6. customto give a solid which
  7. customwas recrystallised from ethyl acetate

출처 및 근거

ORD 기록
ord-f595c9dd513341c196ba5a271675b279
출처 데이터셋
uspto-grants-1988_03
특허 번호
US04728653

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