(E)-4-(1H-imidazol-1-yl)-2-butenamine → HCID 178456322, 화합물

HRID 568491노트

반응식

HRID 568491 반응식
[N:1]1([CH2:6]/[CH:7]=[CH:8]/[CH2:9][NH2:10])[CH:5]=[CH:4][N:3]=[CH:2]1.[IH:11].CS[C:14]1[C:22]2[CH:23]=[CH:24][CH:25]=[C:20]3[C:21]=2[C:16](=[CH:17][CH:18]=[CH:19]3)[N:15]=1>C(O)C>[IH:11].[N:1]1([CH2:6]/[CH:7]=[CH:8]/[CH2:9][NH:10][C:14]2[C:22]3[CH:23]=[CH:24][CH:25]=[C:20]4[C:21]=3[C:16](=[CH:17][CH:18]=[CH:19]4)[N:15]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

참가 물질

4

반응물 2

HCID 13371079(E)-4-(1H-imidazol-1-yl)-2-butenamineHCID 201506502-Methylthiobenz(cd)indole hydriodide

생성물 1

HCID 178456322HCID 178456322, 화합물수율 63.6%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
-10 °C

실험 절차

A mixture of 5.0 g of (E)-4-(1H-imidazol-1-yl)-2-butenamine, 11.5 g of 2-(methylthio)benz[cd]indole hydroiodide and 400 ml of ethanol was stirred and heated at reflux for 16 hours, then clarified while hot. The filtrate was concentrated to 250 ml, cooled to -10° C. and the resulting solid collected, washed with ethanol, ether and dried at 60° C. in vacuo, giving 9.3 g of the desired product, mp 152°-155° C. (dec.).

후처리

  1. temperatureheated
  2. temperatureat reflux for 16 hours
  3. concentrationThe filtrate was concentrated to 250 ml
  4. customthe resulting solid collected
  5. washwashed with ethanol, ether
  6. customdried at 60° C. in vacuo

출처 및 근거

ORD 기록
ord-68081b6f88f141f8bbfdbcfad243a3dd
출처 데이터셋
uspto-grants-1988_03
특허 번호
US04728663

반응 노트

불러오는 중…