Triethylamine → 3-Methoxyphenethyl mesylate
반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[CH2:6][CH2:7][OH:8].C(N(CC)CC)C.[CH3:19][S:20](Cl)(=[O:22])=[O:21]>C(Cl)Cl>[CH3:19][S:20]([O:8][CH2:7][CH2:6][C:5]1[CH:9]=[CH:10][CH:11]=[C:3]([O:2][CH3:1])[CH:4]=1)(=[O:22])=[O:21]참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
To a flask under argon was added 10.1 g (0.0661 mole) 3-methoxyphenethyl alcohol, 150 mL methylene chloride and 9.2 ml (0.0661 mole) triethylamine. The solution was cooled to 0° C. and 5.1 ml (0.0661 mole) methanesulfonyl chloride was added slowly. The reaction mixture was warmed to room temperature. After 24 hr, the reaction was washed with water and brine, and dried with MgSO4. The solvent was evaporated in vacuo to give 15.0 g of the product as a clear oil.
후처리
- temperatureThe reaction mixture was warmed to room temperature
- washthe reaction was washed with water and brine
- dry with materialdried with MgSO4
- customThe solvent was evaporated in vacuo
출처 및 근거
- ORD 기록
- ord-6c28129db84e4fc69e5d5e66e6fd20c1
- 출처 데이터셋
- uspto-grants-1988_03
- 특허 번호
- US04729994
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