Piperazine → Sarafloxacin

HRID 568820

반응식

HRID 568820 반응식
Cl[C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:22])[C:7]([C:19]([OH:21])=[O:20])=[CH:8][N:9]2[C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)=[CH:4][C:3]=1[F:23].[NH:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>>[F:23][C:3]1[CH:2]=[CH:11][C:10]([N:9]2[C:12]3[C:13](=[CH:14][C:15]([F:18])=[C:16]([N:24]4[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]4)[CH:17]=3)[C:6](=[O:22])[C:7]([C:19]([OH:21])=[O:20])=[CH:8]2)=[CH:5][CH:4]=1

참가 물질

3

반응물 2

HCID 4837PiperazineHCID 573387-Chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

생성물 1

HCID 56208Sarafloxacin

실험 절차

In the described fashion as Example 1(e), the above acid (7) R6 =H, R=p-fluorophenyl), after reacting with the piperazine, can give the desired 1-p-fluoro-phenyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid (9) ##STR17## R=p-fluorophenyl) and its hydrochloride salt.

출처 및 근거

ORD 기록
ord-a2bc4f42b32b4c059a13d274628e928d
출처 데이터셋
uspto-grants-1988_03
특허 번호
US04730000

연결된 노트

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