Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(+/-)-cis-1-Methylethyl 6-(cyanomethyl)-2,2-dimethyl-1,3-dioxane4-acetate → Atorvastatin Impurity 206
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (+/-)-cis-1-Methylethyl 6-(cyanomethyl)-2,2-dimethyl-1,3-dioxane4-acetate | HCID 10999646 | — |
| 촉매 | Adams' catalyst | HCID 345198 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | Atorvastatin Impurity 206 | HCID 11139823 | — |
반응 단계
A mixture of (±)-cis-1-methylethyl 6-(cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetate, 0.55 g, in glacial acetic acid is hydrogenated with platinum dioxide at 50 pounds per square inch (PSI). Concentration, dilution with ethyl acetate and bicarbonate wash, followed by washing with brine and drying provides 250 mg of (±)-cis-1-methylethyl 6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate. MS 260.1, 244.1
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05245047 |
| 출처 데이터셋 | uspto-grants-1993_09 |
| ORD ID | ord-1a331950e4dd4997b61684a90a5e772a |
| 출처 메모 | uspto-grants-1993_09 |