Salicylaldehyde → 2-Undecyloxybenzaldehyde

HRID 568900

반응식

HRID 568900 반응식
[CH:1](=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].[CH2:10](Br)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O.CCCCCC>[CH2:20]([O:4][C:3]1[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=1[CH:1]=[O:9])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH3:10]

참가 물질

6

반응물 3

HCID 6998SalicylaldehydeHCID 11430Potassium CarbonateHCID 127441-Bromoundecane

생성물 1

HCID 156174952-Undecyloxybenzaldehyde

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8058Hexane용매

반응 조건

온도
100 °C

실험 절차

A mixture of salicylaldehyde (10.15 moles), undecylbromide (10.3 mmoles) and potassium carbonate (11.7 mmoles) in dimethylformamide (10 ml) is heated to 100° C. for 1 hour and then is cooled. The reaction mixture is taken up in hexane and is washed with 5 percent sodium hydroxide and brine. After treatment with anhydrous magnesium sulfate and charcoal, the volatiles are removed under vacuum and the residue is purified by flash chromatography to give the desired product.

후처리

  1. temperatureis cooled
  2. washis washed with 5 percent sodium hydroxide and brine
  3. customAfter treatment with anhydrous magnesium sulfate and charcoal, the volatiles are removed under vacuum
  4. customthe residue is purified by flash chromatography

출처 및 근거

ORD 기록
ord-d9caa7c1dfbc432fa3184d36e17ae606
출처 데이터셋
uspto-grants-1988_03
특허 번호
US04730005

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