Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Nitrobenzaldehyde → Nicardipine Impurity 19
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Nitrobenzaldehyde | HCID 7449 | — |
| 반응물 | Acetoacetate | HCID 6971017 | — |
| 반응물 | 2-Cyanoethyl 3-aminocrotonate | HCID 13671410 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | Nicardipine Impurity 19 | HCID 10429284 | 88.4% |
반응 단계
10.3 g of 3-nitratopropyl acetoacetate, 7.7 g of 2-cyanoethyl 3-aminocrotonate and 7.6 g of 3-nitrobenzaldehyde in 76 ml of isopropyl alcohol were heated at reflux for 6.5 hours, and cooled on ice. The crystals which precipitated were collected by filtration, dried, applied to a silica gel column chromatography (eluent: dichloromethane) and recrystallized from ethanol to give 16.4 g of 2,6-dimethyl-4-(3-nitrophenyl)1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-cyanoethyl) ester 5-(3-nitratopropyl) ester.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04730052 |
| 출처 데이터셋 | uspto-grants-1988_03 |
| ORD ID | ord-cf05da0d5c2c4a7cb1ab8b92df4a8cd5 |
| 출처 메모 | uspto-grants-1988_03 |