Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 2,2-Difluoro-5-methoxy-1-pentanal oxime
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | Hydroxylamine, N-chloro- | HCID 149953 | — |
| 반응물 | 2,2-Difluoro-5-methoxy-1-pentanal hydrate | HCID 20149453 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Carbon Tetrachloride | HCID 5943 | — |
| 용매 | Sodium chloride; water | HCID 57417360 | — |
| 생성물 | 2,2-Difluoro-5-methoxy-1-pentanal oxime | HCID 73664053 | 91% |
반응 단계
A mixture of 2,2-difluoro-5-methoxy-1-pentanal hydrate (1.57 g, 9.2 mmoles), hydroxylamino hydrochloride (640 mg, 9.2 mmoles), 1N NaOH (9.2 ml), and dioxane (15 ml) is kept for 1 hour at room temperature. After addition of ether and brine, usual extraction gives an oil which according to NMR is the oxime hydrate. Several evaporations with carbon tetrachloride (50° C., 60 mm Hg) afford the oxime (1.4 g) which is purified by chromatography on silica (ethyl acetate/petroleum ether: 20/80, RF: 0.53): 1.05 g (68%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04730006 |
| 출처 데이터셋 | uspto-grants-1988_03 |
| ORD ID | ord-cdffc9b431c346c79072bd402f130673 |
| 출처 메모 | uspto-grants-1988_03 |