HCID 20148433, 화합물 → HCID 13315116, 화합물

HRID 569027노트

반응식

HRID 569027 반응식
[N:1]1([C:7]2[CH:8]=[C:9]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15]2[CH:14]=[N:13][C:12](C(O)=O)=[C:11]([CH3:23])[C:10]3=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>N1C2C(=CC=CC=2)C=CC=1.[Cu]>[N:1]1([C:7]2[CH:8]=[C:9]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15]2[CH:14]=[N:13][CH:12]=[C:11]([CH3:23])[C:10]3=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

참가 물질

4

반응물 1

HCID 20148433HCID 20148433, 화합물

생성물 1

HCID 13315116HCID 13315116, 화합물수율 32.2%

시약·촉매·용매 2

HCID 23978Copper촉매HCID 7047Quinoline용매

실험 절차

2.5 g of 6-piperidino-4-methyl-β-carboline-3-carboxylic acid are heated with 520 mg of copper powder in 50 ml of quinoline for 1.5 hours to 190°-220° C. bath temperature. After distilling off the quinoline in a bulb tube, it is dispersed in ethyl acetate/10% aqueous ammonia. The precipitate that is formed is filtered off and absorptively precipated with ethanol. The combined evaporation residue of the ethanol extraction and the ethyl acetate phase yields 690 mg of 6-piperidino-4-methyl-β-carboline with a 235°-238° C. (decomposition) melting point by crystallization from ethylacetate/diisopropylether.

후처리

  1. distillationAfter distilling off the quinoline in a bulb tube
  2. additionit is dispersed in ethyl acetate/10% aqueous ammonia
  3. customThe precipitate that is formed
  4. filtrationis filtered off and absorptively precipated with ethanol
  5. customThe combined evaporation residue of the ethanol extraction

출처 및 근거

ORD 기록
ord-8a42dd8bae574832a6a9bfa66373b0b3
출처 데이터셋
uspto-grants-1988_03
특허 번호
US04731358

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