2-Sulfamoyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine → 2-Sulfamoyl-4,5-dihydrothieno[2,3-c]pyridine
반응식
[S:1]([C:5]1[S:13][C:8]2[CH2:9][NH:10][CH2:11][CH2:12][C:7]=2[CH:6]=1)(=[O:4])(=[O:3])[NH2:2]>C(OCC)(=O)C.[O-2].[O-2].[Mn+4]>[S:1]([C:5]1[S:13][C:8]2[CH:9]=[N:10][CH2:11][CH2:12][C:7]=2[CH:6]=1)(=[O:3])(=[O:4])[NH2:2]참가 물질
4
반응 조건
- 온도
- 80 °C
실험 절차
To a partial suspension of 2-sulfamoyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine (3.05 g, 14 mmol) in ethyl acetate (200 ml) was added activated manganese dioxide (3.0 g). This mixture was warmed to 80° C. Every two hours an additional 3.0 g of activated manganese dioxide was added until 12 g total had been added. This mixture was filtered hot and the collected manganese dioxide was re-extracted with hot ethyl acetate. The combined ethyl acetate extracts were evaporated to give 2.1 g of crude product. This material was purified by chromatography on silica gel eluting with a gradient 0-5% methanol/ethyl acetate. Recrystallization from ethyl acetate gave pure product (0.8 g, 26.5% yield); m.p. 161°-164° C.