참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 4-Chlorothieno[3,2-c]pyridine-2-sulfonamide | HCID 20148583 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-Sulfamoylthieno[3,2-c]pyridin-4(5H)-one | HCID 20148557 | 66% |
반응 단계
A solution of 2-sulfamoyl-4-chlorothieno[3,2-c]pyridine (0.87 g, 3.5 mmol) in 10 N sodium hydroxide (1.8 ml) diluted with water (7 ml) was heated at 100° C. for 5-10 hours. After cooling the reaction and acidification with concentrated hydrochloric acid, the precipitated product was collected by filtration. Recrystallization from hot dimethyl sulfoxide by dilution with ethanol gives 0.53 g (66% yield) of product; m.p. 299°-301° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04731368 |
|---|
| 출처 데이터셋 | uspto-grants-1988_03 |
|---|
| ORD ID | ord-ef57163a5e684e049f1b51872253b2cb |
|---|
| 출처 메모 | uspto-grants-1988_03 |
|---|
