Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl iodide → 4-[N-(4-Chloro-benzyl)-methylamino]-cyclohexanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-(4-Chloro-benzylamino)-cyclohexanol | HCID 13670658 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-[N-(4-Chloro-benzyl)-methylamino]-cyclohexanol | HCID 13670660 | — |
반응 단계
7.2 g (30 mMol) of 4-[N-(4-chloro-benzyl)-amino]-cyclohexanol are dissolved in 30 ml of dimethyl-formamide, and after the addition of 2.2 g (16 mMol) of potassium carbonate, 4.26 g (30 mMol) of methyliodide are added dropwise. When the slightly exothermic reaction has ended, the mixture is concentrated by evaporation, mixed with water and extracted with chloroform. The concentrated extracts are chromatographed on silica gel to purify them (eluant; methylene chloride/methanol=20/1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04731374 |
| 출처 데이터셋 | uspto-grants-1988_03 |
| ORD ID | ord-cf350ff17b494516829bc7e2dc5d9f47 |
| 출처 메모 | uspto-grants-1988_03 |