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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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2-Hydroxyisobutyric acid → HCID 53668099, 화합물

HRID 569309
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인쇄 미리보기

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HRID 569309 반응식
[C:1]([O:4][CH2:5][CH2:6][C:7]12[CH2:19][CH2:18][C:17](=[O:20])[CH:16]=[C:15]1[C:14]1[C:9](=[CH:10][C:11]([O:23][CH2:24][C:25]([OH:27])=[O:26])=[C:12]([Cl:22])[C:13]=1[Cl:21])[CH2:8]2)(=[O:3])[CH3:2].C(N1C=CN=C1)(N1C=CN=C1)=O.O[C:41]([CH3:46])([CH3:45])[C:42]([OH:44])=[O:43]>O1CCCC1>[C:1]([O:4][CH2:5][CH2:6][C:7]12[CH2:19][CH2:18][C:17](=[O:20])[CH:16]=[C:15]1[C:14]1[C:9](=[CH:10][C:11]([O:23][CH2:24][C:25]([O:27][C:41]([C:42]([OH:44])=[O:43])([CH3:46])[CH3:45])=[O:26])=[C:12]([Cl:22])[C:13]=1[Cl:21])[CH2:8]2)(=[O:3])[CH3:2]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 116712-Hydroxyisobutyric acidHCID 682631,1'-CarbonyldiimidazoleHCID 20148928HCID 20148928, 화합물

생성물 1

HCID 53668099HCID 53668099, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
20 °C

실험 절차

{[9a-(Acetoxyethyl)-5,6-dichloro-3-oxo-2,3,9,9a-tetrahydro-1H-fluoren-7-yl]oxy}acetic acid (4.13 g, 10 mMole) is dissolved in dry tetrahydrofuran (20 ml). 1,1'-Carbonyldiimidazole (3.2 g, 10 mMole) is added and the mixture stirred at 20° C. for an hour. 2-Hydroxy-2-methylpropionic acid (1.05 g, 10 mMole) is added and the mixture stirred for 18 hours at 20° C. The solvent is removed by evaporation in vacuo. The residue is dissolved in methylene chloride, washed with water and dried over MgSO4. The solvent is removed by evaporation in vacuo and the residue purified by chromatography using a silica gel column with methylene chloride/tetrahydrofuran/acetic acid 100/2/1 (V.V.V.) as the eluent. Selecting the appropriate cuts gave the desired compound upon evaporation of the solvent in vacuo.

후처리

  1. stirringthe mixture stirred for 18 hours at 20° C
  2. customThe solvent is removed by evaporation in vacuo
  3. dissolutionThe residue is dissolved in methylene chloride
  4. washwashed with water
  5. dry with materialdried over MgSO4
  6. customThe solvent is removed by evaporation in vacuo
  7. customthe residue purified by chromatography

출처 및 근거

ORD 기록
ord-127353321aa74dda8d5621238af7e372
출처 데이터셋
uspto-grants-1988_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04731471

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