Malonic Acid → (E)-3-[3-(1-Octynyl)-2-furanyl]prop-2-enoic acid

HRID 569486

반응식

HRID 569486 반응식
[C:1]([C:9]1[CH:13]=[CH:12][O:11][C:10]=1[CH:14]=O)#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].C(O)(=O)[CH2:17][C:18]([OH:20])=[O:19]>CCCCCC>[C:1]([C:9]1[CH:13]=[CH:12][O:11][C:10]=1/[CH:14]=[CH:17]/[C:18]([OH:20])=[O:19])#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

참가 물질

4

반응물 2

HCID 867Malonic AcidHCID 201471613-(1-Octynyl)furan-2-carboxaldehyde

생성물 1

HCID 20147178(E)-3-[3-(1-Octynyl)-2-furanyl]prop-2-enoic acid수율 88%

시약·촉매·용매 1

HCID 8058Hexane용매

실험 절차

Reaction of 3-(1-octynyl)furan-2-carboxaldehyde (1.02 g, 5 mmole from example 14) with malonic acid (1.04 g, 10 mmole) as described in Example 2 gave 1.08 g (88%) of the title compound, mp (Hexane) 81°-81.5° C., νmax (mull) 2600(broad), 1690, 1670(sh), 1620, 1410, 1320, 1270, 970, 890, 770 cm-1 ; δ(CDCl3) 0.91(3H, t, J=6.9 Hz), 1.34(2H, m), 1.46(2H, m), 1.62(2H, m), 2.45(2H, t, J=7.0 Hz), 6.40(1H, d, J=15.9 Hz), 6.46(1H, d, J=1.8 Hz), 7.41(1H, d, J=1.8 Hz), 7.66(1H, d, J=15.9 Hz), 11.60(1H, broad).

출처 및 근거

ORD 기록
ord-49a330b61e114760ab6fb718c2ba2641
출처 데이터셋
uspto-grants-1988_03
특허 번호
US04732901

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